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WEBGeneRIFs: Gene References Into Functions. Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle. Attenuation of SLD5 expression results in marked DNA damage in both normal cells and cancer cells, suggesting that it protects against DNA damage. Requirement of SLD5 for early embryogenesis.
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WEBTo identify the PSF1-binding protein, we used the yeast two-hybrid system with PSF1 as bait, and identified and cloned SLD5. SLD5 interacted with a central region of PSF1. Tissue distribution of SLD5 was quite similar to that of PSF1. When overexpressed, SLD5 protein was co-localized with PSF1. These data suggest that PSF1 and SLD5 may ...
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WEBTo further investigate whether SLD5 interacts with M1 during influenza virus infection, 293T were transfected with GFP‐flag or SLD5‐flag constructs and infected with PR8 virus. As shown in Figure 1e, SLD5 specifically immunoprecipitated M1 after PR8 infec-tion. Collectively, our data validated that M1 interacts with SLD5 in vitro and in vivo.
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WEBA DNA replication complex GINS protein SLD5 that is encoded in the genome of Dictyostelium discoideum. Protein Ontology. The GINS complex plays an essential role in the initiation of DNA replication. UniProt. 1 Names and Identifiers. 1.1 Synonyms. DNA replication complex GINS protein SLD5 ;
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WEBRecently, we cloned mouse PSF1 from a hematopoietic stem cell specific cDNA library and reported that PSF1 is indispensable for the proliferation of immature cells. To identify the PSF1-binding protein, we used the yeast two-hybrid system with PSF1 as bait, and identified and cloned SLD5. SLD5 interacted with a central region of PSF1.
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WEBde 95 à 295 mm de longueur. Cheville à frapper en PVC avec clou métallique pour la fixation des isolants dans les systèmes d' Isolation Thermique par l'Extérieur webertherm. Ajouter dans MyWeber Trouver un distributeur. Comparer. Accès direct : Bon à savoir. Caractéristiques et avantages produits.
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WEBSld5 is one component of the GINS heterotetrameric complex essential to DNA replication. Specifically, GINS is known for its integral role during the G1 to S phase transition in the cell cycle. The GINS complex is comprised of multiple subunits: Psf1, Psf2, Psf3 and Sld5, all of which are highly conserved in eukaryotes. ...
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WEBweber.therm Schlagdübel SLD-5. Robuster Dübel für alle Untergründe! Dieser stabile, umspritzte Schlagdübel wurde speziell für eine wirtschaftliche, robuste Arbeitsweise entwickelt. weber.therm WDVS-Zubehör-Konfigurator.
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WEBMoreover, we found that high levels of SLD5 in bladder cancer cells result from downregulation of microRNA (miR)-370 that otherwise suppresses its expression. High level expression of DNA-methyltransferase (DNMT) 1 and IL-6 were also observed in bladder cancer cells. Knockdown of IL-6 led to downregulation of DNMT1 and SLD5 …
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WEBTargeted disruption of murine SLD5 and expression of SLD5 during early embryogenesis. (A) Generation of SLD5-deficient mice. Exons of SLD5 were replaced by homologous recombination with a β-galactosidase-encoding gene (lacZ) fused to a neomycin resistance gene driven by the MC1 promoter (Neo). This targeted mutation …
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WEBGINS complex protein. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA ...
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WEBSLD钢材为高碳、高铬型合金钢、具极高硬度及适宜之轫性,并有回火硬化效果,为典型之风硬钢,是耐磨耗性较好之 合金工具钢 。. 中文名. SLD钢材. 锻 制. 1050℃—950℃. 硬 度. HRC61℃以上. 特 点. 相对较好的韧性.
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WEB阿里巴巴原装现货sld4-12gn-nk1c2u汇川inovance接近开关sld5-q18cn-nk1c2,plc,这里云集了众多的供应商,采购商,制造商。这是原装现货sld4-12gn-nk1c2u汇川inovance接近开关sld5-q18cn-nk1c2的详细页面。产地:中国,是否进口:否,订货号:sld4-12gn-nk1c2u,加工定制:是,货号:sld4-12gn-nk1c2u,品牌:其他,型号:sld40-30gn-pk1c2 ...
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WEBSLD5 is a member of the GINS complex, essential for DNA replication in eukaryotes. It has been reported that SLD5 is involved in early embryogenesis in the mouse and cell cycle progression and ...
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WEBIn this study, we found that M protein of several other RNA viruses, including VSV, SeV and HIV, interacted with SLD5. Furthermore, VSV/SeV infection and M protein of VSV/SeV/HIV induced cell ...
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WEBProteintech Anti-SLD5 Polyclonal, Catalog # 13315-1-AP. Tested in Western Blot (WB) applications. This antibody reacts with Human, Mouse samples. Supplied as 150 µL purified antibody (0.33 mg/mL).
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WEBThe Sld5 subunit of the GINS complex was first identified in the budding yeast S. cerevisiae as synthetically lethal with a mutation in dpb11, a protein required for the loading of DNA polymerase epsilon [10,11]. Although a number of biochemical, tissue culture, and gene expression studies have characterized the GINS complex, no studies have ...
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WEBThe SLD5 7aa mutant failed to bind Psf2, which might disrupt the formation of the GINS complex. Second, expression of M1 delayed cell cycle progress. Moreover, M1 induced cell cycle arrest was dependent on the domain of 170 N, which interacts with SLD5. Third, SLD5 partially rescued influenza virus infection-induced cell cycle arrest.
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WEB簡介sld鋼材為高碳、高鉻型合金鋼、具極高硬度及適宜之軔性,並有回火硬化效果,為典型之風硬鋼,是目前耐磨耗性較好之合金工具鋼。添加鉬、釩元素,故兼具耐磨、不變形、耐衝擊等特性。經二次精煉,清淨度佳,
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WEBwebertherm espiga SLD 5. Fijación mecánica con núcleo metálico. Anclaje universal de golpeo con núcleo metálico para la fijación de materiales aislantes en los sistemas webertherm sobre substratos catalogados como A (hormigón o panel de hormigón), B (ladrillo cerámico macizo), C (ladrillo cerámico hueco o bloque de hormigón), D ...
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WEB高靭性・高切削性 新冷間ダイス鋼 sld®-fのページです。proterialは、金属材料、機能部材の2つの事業で、独自の開発力と技術力を磨いてきました。お客様の多様なニーズに応 …
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WEBSLD5 forms a GINS complex with PSF1, PSF2 and PSF3, which is essential for the initiation of DNA replication in lower eukaryotes. Although these components are conserved in mammals, their biological function is unclear. We show here that targeted disruption of SLD5 in mice causes a defect in cell proliferation in the inner cell mass, …
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WEBCDC45 SLD5. Affinity Capture-MS. Affinity Capture-MS. An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. Michaelis AC (2023) High.
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WEB日立金属 SLD のカタログデータの見方. 日立金属のSLDは、SKD11の相当品として、冷間工具鋼などの、いろいろな用途に幅広く使用されています。. 入手しやすく、価格も …
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WEBセラミックス. タカギスチールの【素材】冷間工具鋼（SLD-MAGIC、SKD11など）の技術や価格情報などをご紹介。. SLD-MAGIC、SKDll、SKS、SKなど …
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WEBGINS is a heterotetrameric complex consisting of Sld5, Psf1 (partner of Sld5-1), Psf2, and Psf3 and was first discovered by using a variety of genetic screens in S. cerevisiae ().The four GINS subunits are …
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WEBWe demonstrated that Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase. Depletion of SIK1 leads to defective DNA replication. Further, we showed that SIK1 phosphorylates MCM2 at five conserved residues at its N-terminus, which is essential for the activation of MCM helicase.
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WEBThe Sld5 gene is found on chromosome 3R in the Drosophila genome and is located in close proximity to Dak1 (Fig. 1A). Transcript models for this region suggest that Sld5 and Dak1 may be part of a multi-cistronic transcript [19] (Fig. 1A). Two independent, recessive lethal, ...
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WEBThe extracts were either treated with DNase or left untreated before isolation of replisome material by immunoprecipitation of TAP-Sld5. (B) mec1Δ TAP-SLD5 (YGDP865) and mec1Δ TAP-SLD5 CDC45-5FLAG (YGDP767) were released into S phase for 90 min in the presence 0.2 M HU, and TAP-SLD5 isolated as above.
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WEBSLD5 Antibody (D-7) is an IgG 1 κ mouse monoclonal SLD5 antibody (also designated SLD5 antibody) that detects the SLD5 protein of human origin by WB, IP, IF and ELISA. SLD5 Antibody (D-7) is available as both the non-conjugated anti-SLD5 antibody form, as well as multiple conjugated forms of anti-SLD5 antibody, including agarose, HRP, PE, …
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